New Perspectives in Therapy of Intoxications by Organophosphoric Compounds

V. Sunel1, M. Popa2, C. L. Dumitriu2 and O. Pintilie1

1"Al. I. Cuza" University, Faculty of Chemistry, Department of Organic Chemistry,

Bd. Carol, 11, 6600 Iasi, Romania

2 "Gh.Asachi" Technical University, Faculty of Industrial Chemistry, Department of Macromolecules, Bd. D. Mangeron, 71 A, 700050 Iasi, Romania,


Little references actually exist on neutralization therapy which could constitute the missing ring from an efficient treatment. As structural model capable to interact with organophosphoric substances, at the level of phosphor (P) atom, the common chemical element of the hole class of substances, was proposed those of benzimidazole. Different quantities of benzimidazole were put in contact with a fix quantity of trichlorphon in acid conditions and formation of a new compound was evidentiated by infrared spectrometry. Similar experiments were made utilizing benzimidazole derivatives (2 methyl or 2 benzyl benzimidazole) and different temperatures: 35C and 40C. By increasing massic rate: benzimidazole/triclorfon as well an increased reaction temperature, have favourably influenced trichlorphon capture. The obtained results justified an continuation of researches in the direction of new compounds with a structure similar with that of benzimidazole for funding an efficient neutralization therapy for organophosphoric substances.