Xanthan and Poly(vinyl alcohol) - Based Composite Films, as Supports for Chloramphenicol Immobilization

Alupei Iulian Corneliu1, Popa Marcel2, Hamcerencu Mihaela2,

Savin Alexandru2, Abadie Marc Jean3

1"Gr. T.Popa" University of Medicine and Pharmacy, Faculty of Medical Bioengineering,

Universitatii str, nr. 16, 6600 Iasi, Romania

2"Gh. Asachi" Technical University, Faculty of Chemical Engineering,

Bd. D. Mangeron, nr. 71, 6600 Iasi, Romania

3LEMP/MAO, Montpellier II University, Place Eugиne Bataillon, 34095 Montpellier Cedex 05, France

Abstract

The paper discusses a method for the realization of some polymer - drug systems in which the macromolecular support is represented by a three-dimensional network based on xanthan and poly(vinyl alcohol). Knowing that the drug (chloramphenicol) was to be inserted through a diffusion process, the support – selected according to an experimental program – had the highest degree of swelling.

Several variants of chloramphenicol inclusion into the synthesized support are analyzed by studying the process kinetics. The study of chloramphenicol release from the inclusion products, in the form of films, indicated the installation of a "zero order" kinetics.

The tests devoted to the system’s antimicrobial activity evidenced their biological action.