Interaction of Chitosan with Hydrogel of Poly(Acrylic Acid)

and Preparation of Encapsulated Drugs

Yin Jing Bo1, Vitaliy V. Khutoryanskiy2, Victor A. Kan2, Yulia R. Gabdulina2,

Grigoriy A. Mun2, Zauresh S. Nurkeeva2

1Ji Lyn Polytechnic Institute, Yan An Str. 17, 130012 Chanchun, People Republic of China

2Kazakh State National University, Department of Chemical Physics & Macromolecular Chemistry, Karasai Batyr Str. 95, 480012 Almaty, Kazakhstan

Abstract

The complexation of linear chitosan with hydrogel of poly(acrylic acid) was studied in acetic acid solutions. It was found that the complexation is accompanied by contraction of hydrogel samples with formation of turbid layer on their surface. The dynamic changes of swelling ratio of poly(acrylic acid) hydrogel in course of the interaction with chitosan are interpreted from the diffusion theory point of view considering the properties of double electric layer on hydrogel-solution boundary. The FTIR spectroscopy method revealed the electrostatic mechanism of interaction between poly(acrylic acid) hydrogel and chitosan. The spectrum of polycomplex shows the bands, which are characteristic for both poly(acrylic acid) (1725, 1450, 1249 cm-1) and chitosan (1648, 1536, 1165, 1091, 1023 cm-1) confirming the sorption of the later polymer by hydrogel of poly(acrylic acid). The possibility of encapsulation of antibiotic levomycetin into polycomplex hydrogels as well as its release from the capsules has been studied. It was found that the maximal value of the drug released from the polycomplex capsule is achieved after the longer period in comparison with control experiment with its release from pure PAA hydrogel. It was shown that the interpolymer interactions between oppositely charged linear polymers and hydrogels could be successfully used for preparation of encapsulated forms of various physiologically active substances.